Cardiology Rounds Team's Page

Objectives: The purpose of this study was to determine whether single-dose rosuvastatin (40 mg) protects against ischemia and reperfusion (IR)–induced endothelial dysfunction in humans and whether this effect is cyclooxygenase (COX)-2 dependent.

Background: Animal studies have demonstrated that rosuvastatin can limit damage and improve recovery after IR.

Methods: In a double-blind, parallel design, 20 volunteers were randomized to a single dose of oral rosuvastatin (40 mg) or placebo.

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Cardiovascular disease (CVD) is the leading cause of death in the western world and a leading cause of death worldwide. Assessing patients' cardiovascular risk may be used to target preventive treatments to asymptomatic individuals at high risk for future CVD events. For these high-risk individuals, strategies including medication, diet, and comprehensive lifestyle approaches have been shown to improve cardiovascular morbidity and morta… Continue

Context A low ankle brachial index (ABI) indicates atherosclerosis and an increased risk of cardiovascular and cerebrovascular events. Screening for a low ABI can identify an asymptomatic higher risk group potentially amenable to preventive treatments.

Objective To determine the effectiveness of aspirin in preventing events in people with a low ABI iden

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Traditional nonsteroidal anti-inflammatory drugs are associated with
the destabilization of blood pressure (BP) control, particularly in
hypertensive patients treated with blockers of the renin-angiotensin
system. To assess the potential impact of nitric oxide donation, the
effects of naproxcinod with naproxen and placebo on changes in BP were
compared in a randomized clinical trial of 916 patients with
osteoarthritis after 13 weeks of therapy. In addition, the effects of
naproxcinod versus napr… Continue

BACKGROUND: The aim of this study was to assess the most relevant
echocardiographic parameter for the clinical diagnosis of acute dyspnea
due to left-heart dysfunction. METHODS: Transthoracic echocardiography
was performed in 88 patients in sinus rhythm admitted for respiratory
distress. Two experts determined the cause of dyspnea as cardiogenic
(26 patients) or noncardiogenic (62 patients). RESULTS: The feasibility
was 100% for the E/A ratio and the E/E deceleration time (EDT) ratio
but 97%, 89… Continue